• 30 SEP 14

    Researchers Contribute to Study of Trained Immunity

    A study published in the journal Science provides support for a new — and still controversial — understanding of the immune system. The research was conducted by collaborators in the U.S. and Europe, including Robert Cramer, PhD, an assistant professor of microbiology and immunology at the Geisel School of Medicine and member of the Dartmouth Lung Biology Center, and Kelly Shepherdson, PhD, at the time a graduate student in Cramer’s lab. Read more about the study here 

    This study documents for cancer patients two important implications both for

    1) the prevention and treatment of inflammatory diseases and for bolstering the immune response to pathogens in situations where the immune system is not functioning properly and

    2) to prevent and treat probably all forms of cancer, as cancer is usually the result of chronic inflammation.

    It is of utmost importance to realize that there is a huge difference between acute inflammation (with fever) and chronic inflammation (no fever). In general, one could say that acute inflammation “is good for you.”

    Therefore in the Medical Center Cologne, cancer patients are often treated with “fever-range, total-body hyperthermia” (moderate fever). And in chronic viral infections like in Hepatitis B and C, often a few times going through a therapeutic form of moderate fever period, improves and can even overcome the chronic infection. Also with certain medications made of the unripe tomato, one can bring about a mild inflammation (“irritation”) of the liver with elevation of the liver enzymes and then, the chronic infection is turned from chronic into acute, and a recovery is still possible.

    If one can figure out these underlying mechanisms, one might be able to enhance the efficacy of vaccines and improved treatment of cancer. The consequences of this study indicates that doctors and scientists must rethink the traditional understanding of the immune system (specifically in chronic inflammation and cancer).”

    Robert Gorter, MD, PhD: “The bottom line is that acute inflammation (with fever) are essentially always good for you where as chronic inflammation is always bad for you and is an indication of an increasing immunodeficiency (“Burn Out” of the immune system).”

    facebook Researchers Contribute to Study of Trained Immunitytwitter Researchers Contribute to Study of Trained Immunitygoogle Researchers Contribute to Study of Trained Immunitylinkedin Researchers Contribute to Study of Trained Immunitypinterest Researchers Contribute to Study of Trained Immunity
Share on FacebookTweet about this on TwitterShare on Google+Share on LinkedInPin on Pinterest